Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850743 | 0.89 | EDNRA (0.45) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7849615 | 0.88 | EDNRA (0.51) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7853910 | 0.87 | EDNRA (0.50) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7849633 | 0.84 | MAPT (0.47) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7006902 | 0.81 | EDNRA (0.70) | EDNRAALDH1A1MEN1KMT2A | |
| SCHEMBL7008278 | 0.81 | EDNRA (0.70) | EDNRAALDH1A1MEN1KMT2A | |
| SCHEMBL7006905 | 0.81 | EDNRA (0.70) | EDNRAALDH1A1MEN1KMT2A | |
| SCHEMBL7006907 | 0.80 | EDNRA (0.42) | EDNRAMAPTL3MBTL1PIK3CAHTR7 | |
| SCHEMBL7850538 | 0.79 | MAPT (0.48) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA | |
| SCHEMBL7849612 | 0.78 | EDNRA (0.51) | EDNRAMAPTL3MBTL1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837708-A | CARDIOVASCULAR DISORDERS OF HYPERTENSION, ISCHEMIA, ANGINA PECTORIS AND VASOSPASMS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-17 | — | — | US | disclosed |