Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 9/20 | 0.42 |
| ▸ | RARB | P10826 | 8/20 | 0.42 |
| ▸ | RARG | P13631 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 6/20 | 0.39 |
| ▸ | RXRG | P48443 | 5/20 | 0.39 |
| ▸ | RARA | P10276 | 5/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292717 | 0.84 | CYP3A4 (0.48) | LMNARXRARARBRARGRXRB | |
| SCHEMBL6292577 | 0.82 | RARB (0.51) | LMNARXRARARBRARGRXRB | |
| SCHEMBL8597955 | 0.81 | KDM4E (0.43) | LMNARXRARARBRARGTDP1 | |
| SCHEMBL6362862 | 0.79 | MAPT (0.47) | LMNARXRARARBRARGTDP1 | |
| SCHEMBL6240160 | 0.79 | NPC1 (0.45) | LMNARXRARARBRARGRXRB | |
| SCHEMBL8632616 | 0.79 | RARB (0.43) | LMNARXRARARBRARGTDP1 | |
| SCHEMBL6814372 | 0.78 | RXRA (0.49) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8771700 | 0.75 | RXRA (0.67) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8125822 | 0.75 | RARG (0.48) | LMNARXRARARBRARGRXRB | |
| SCHEMBL6362860 | 0.75 | RXRA (0.43) | RXRARARBRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773594-A | TREATING SKIN DISORDERS, REDUCING SIDE EFFECTS OF OTHER RETINOIDS | ALLERGAN (US) | 1998-06-30 | — | — | US | disclosed |
| US-5763635-A | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN (US) | 1998-06-09 | — | — | US | disclosed |
| US-5747542-A | SKIN DISORDERS; ANTICANCER AGENTS | ALLERGAN (US) | 1998-05-05 | — | — | US | disclosed |
| US-5741896-A | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN (US) | 1998-04-21 | — | — | US | disclosed |
| US-5723666-A | USEFUL AS REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION | ALLERGAN (US) | 1998-03-03 | — | — | US | disclosed |