Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.67 |
| ▸ | RARB | P10826 | 10/20 | 0.67 |
| ▸ | RXRB | P28702 | 9/20 | 0.67 |
| ▸ | RARG | P13631 | 8/20 | 0.67 |
| ▸ | RXRG | P48443 | 8/20 | 0.67 |
| ▸ | RARA | P10276 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292577 | 0.89 | RARB (0.51) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL6814372 | 0.86 | RXRA (0.49) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL8981652 | 0.81 | RARA (0.69) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL6236585 | 0.81 | RARB (0.67) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL7640552 | 0.81 | RARB (0.67) | RARBRARGRARACYP26A1 | |
| SCHEMBL6759491 | 0.81 | RARB (0.67) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL6236579 | 0.81 | RARB (0.67) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL6818089 | 0.80 | RXRA (1.00) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL6240160 | 0.80 | NPC1 (0.45) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL8771779 | 0.79 | RARB (0.69) | RXRARARBRXRBRARGRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0736530-A2 | Retinoid-like heterocycles | Bristol-Myers Squibb Company (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5559248-A | FOR PREVENTION AND TREATMENT OF SKIN DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |