Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574145 | 0.87 | PTPN1 (0.49) | HPGDMAPTCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL12013989 | 0.85 | MEN1 (0.49) | MEN1KMT2ANCEH1PDE4DCTNNB1 | |
| SCHEMBL11078616 | 0.84 | ALDH1A1 (0.53) | MEN1KMT2AHPGDMAPTCYP1A2 | |
| SCHEMBL5693936 | 0.84 | CA12 (0.57) | MEN1KMT2AKDM4ERAB9AALDH1A1 | |
| SCHEMBL38656246 | 0.84 | CA12 (0.57) | MEN1KMT2AKDM4ERAB9AALDH1A1 | |
| SCHEMBL7772381 | 0.83 | MEN1 (0.51) | MEN1KMT2AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1574514 | 0.80 | NCEH1 (0.41) | SMN1; SMN2NCEH1POLBCYP19A1CYP11B1 | |
| SCHEMBL9860196 | 0.79 | SMN1; SMN2 (0.50) | MEN1KMT2AKDM4ESMN1; SMN2HPGD | |
| SCHEMBL11805818 | 0.79 | CYP19A1 (0.43) | KDM4ERAB9ACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL10545636 | 0.79 | CYP19A1 (0.43) | CYP1A2CYP2C19CYP3A4CYP2C9NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301311-B1 | PROCESS FOR PREPARING NAPROXEN | ZAMBON GROUP S.p.A. (IT) | 1993-01-20 | — | — | EP | claimed |
| US-5053533-A | PROCESS FOR PREPARING NAPROXEN | ZAMBON GROUP SPA (IT) | 1991-10-01 | — | — | US | claimed |
| EP-0301311-A2 | Process for preparing naproxen | ZAMBON GROUP S.p.A. (IT) | 1989-02-01 | — | — | EP | claimed |
| JP-1047733-A | — | — | None | — | — | JP | disclosed |
| US-20130267712-A1 | AROMATIC KETONE SYNTHESIS WITH AMIDE REAGENTS AND RELATED REACTIONS | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2013-10-10 | — | — | US | disclosed |
| EP-0537558-B1 | Process for the dehalogenation of naphthalene derivatives | ZAMBON SPA (IT) | 1998-07-22 | — | — | EP | disclosed |
| US-5268491-A | Process for the dehalogenation of naphthalene derivatives | ZAMBON GROUP S.P.A. (IT) | 1993-12-07 | — | — | US | disclosed |
| EP-0537558-A1 | Process for the dehalogenation of naphthalene derivatives | ZAMBON GROUP S.p.A. (IT) | 1993-04-21 | — | — | EP | disclosed |
| EP-0301311-B1 | PROCESS FOR PREPARING NAPROXEN | ZAMBON GROUP S.p.A. (IT) | 1993-01-20 | — | — | EP | disclosed |
| US-5053533-A | PROCESS FOR PREPARING NAPROXEN | ZAMBON GROUP SPA (IT) | 1991-10-01 | — | — | US | disclosed |
| EP-0301311-A2 | Process for preparing naproxen | ZAMBON GROUP S.p.A. (IT) | 1989-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267712-A1 | AROMATIC KETONE SYNTHESIS WITH AMIDE REAGENTS AND RELATED REACTIONS | NAAA, AADAC, NISCH | MEN1 4420/4885KMT2A 261/4885KDM4E 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.