SCHEMBL8635686

SCHEMBL8635686

Cc1cc(OCC=C(Br)Br)ccc1Oc1ncc(C(F)(F)F)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C19 P33261 1/20 0.47
RAB9A P51151 1/20 0.47
HPGD P15428 2/20 0.46
LIPE Q05469 1/20 0.46
FFAR1 O14842 1/20 0.44
ALDH1A1 P00352 4/20 0.44
HTT P42858 2/20 0.43
MAPT P10636 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
POLB P06746 1/20 0.43
KDM4E B2RXH2 1/20 0.42
XBP1 P17861 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8636962 0.92 SMN1; SMN2 (0.50) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8634563 0.91 SMN1; SMN2 (0.49) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8637756 0.91 LMNA (0.49) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8632953 0.88 PPARD (0.40) LMNASMN1; SMN2FFAR1
SCHEMBL8638909 0.88 RAB9A (0.47) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8633276 0.87 RAB9A (0.46) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8632733 0.87 CYP1A2 (0.51) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8632585 0.85 RAB9A (0.48) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8637913 0.85 CYP1A2 (0.46) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL8633939 0.84 RAB9A (0.53) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed