Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641938 | 0.87 | LTA4H (0.52) | LTA4HS1PR5 | |
| SCHEMBL8642217 | 0.85 | LTA4H (0.42) | LTA4HS1PR5 | |
| SCHEMBL8644367 | 0.83 | LTA4H (0.42) | LTA4HS1PR5PTGS1PTGS2 | |
| SCHEMBL8641269 | 0.80 | LTA4H (0.48) | LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8639324 | 0.79 | LTA4H (0.54) | LTA4HCYP2C19 | |
| SCHEMBL8637399 | 0.76 | LTA4H (0.47) | LTA4H | |
| SCHEMBL8639297 | 0.76 | SCN9A (0.42) | S1PR5CYP2C9CYP2C19 | |
| SCHEMBL8641866 | 0.73 | LTA4H (0.42) | LTA4HS1PR5 | |
| SCHEMBL8639102 | 0.73 | LTA4H (0.42) | LTA4HS1PR5 | |
| SCHEMBL7139263 | 0.72 | LTA4H (0.75) | LTA4HS1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |