Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641866 | 0.90 | LTA4H (0.42) | LTA4HNPC1RAB9ASMN1; SMN2S1PR5 | |
| SCHEMBL8641938 | 0.85 | LTA4H (0.52) | LTA4HHRH1SCN1ASCN2ASCN3A | |
| SCHEMBL8642217 | 0.77 | LTA4H (0.42) | LTA4HS1PR5 | |
| SCHEMBL8639324 | 0.77 | LTA4H (0.54) | LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8637399 | 0.74 | LTA4H (0.47) | LTA4HNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8635904 | 0.73 | LTA4H (0.41) | LTA4HS1PR5 | |
| SCHEMBL8644367 | 0.73 | LTA4H (0.42) | LTA4HL3MBTL1S1PR5ALDH1A1KMT2A | |
| SCHEMBL8639583 | 0.72 | LTA4H (0.46) | LTA4HNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8639136 | 0.70 | SMN1; SMN2 (0.42) | LTA4HSMN1; SMN2CD274ALDH1A1 | |
| SCHEMBL8641861 | 0.70 | LTA4H (0.47) | LTA4HHRH1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |