Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 14/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635912 | 0.89 | LTA4H (0.61) | LTA4HDRD2DRD4FAAHACHE | |
| SCHEMBL8639534 | 0.83 | LTA4H (0.58) | LTA4HFAAHACHECHRM3 | |
| SCHEMBL8641935 | 0.78 | LTA4H (0.61) | LTA4H | |
| SCHEMBL7139205 | 0.78 | LTA4H (1.00) | LTA4H | |
| SCHEMBL8641261 | 0.76 | LTA4H (0.56) | LTA4HFAAHACHE | |
| SCHEMBL8644158 | 0.74 | LTA4H (0.60) | LTA4HCHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL8635915 | 0.74 | LTA4H (0.83) | LTA4H | |
| SCHEMBL9631914 | 0.73 | BCHE (0.54) | LTA4HDRD2DRD4ACHE | |
| SCHEMBL8639527 | 0.73 | LTA4H (0.49) | LTA4HCHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL7141145 | 0.73 | LTA4H (1.00) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |