Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 15/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639327 | 0.91 | LTA4H (0.60) | LTA4HNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL8640788 | 0.87 | DRD3 (0.56) | LTA4HL3MBTL1 | |
| SCHEMBL8641261 | 0.86 | LTA4H (0.56) | LTA4HNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL8637340 | 0.81 | LTA4H (0.63) | LTA4HCCR8 | |
| SCHEMBL8641251 | 0.80 | DRD3 (0.52) | LTA4HL3MBTL1 | |
| SCHEMBL7141718 | 0.78 | LTA4H (1.00) | LTA4H | |
| SCHEMBL7141632 | 0.77 | LTA4H (0.81) | LTA4H | |
| SCHEMBL8639534 | 0.73 | LTA4H (0.58) | LTA4H | |
| SCHEMBL7140388 | 0.73 | LTA4H (1.00) | LTA4HNPC1RAB9A | |
| SCHEMBL7139644 | 0.72 | LTA4H (0.72) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |