Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 14/20 | 0.63 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640066 | 0.87 | LTA4H (0.56) | LTA4H | |
| SCHEMBL8644158 | 0.86 | LTA4H (0.60) | LTA4H | |
| SCHEMBL8635995 | 0.81 | LTA4H (0.64) | LTA4HCCR8 | |
| SCHEMBL28783135 | 0.80 | CCR8 (0.49) | LTA4HCCR8 | |
| SCHEMBL8641935 | 0.78 | LTA4H (0.61) | LTA4HEGFRCCR8 | |
| SCHEMBL26454342 | 0.78 | EGFR (0.59) | LTA4HEGFRCCR8 | |
| SCHEMBL1900326 | 0.77 | LTA4H (1.00) | LTA4HEGFR | |
| SCHEMBL8637149 | 0.76 | LTA4H (0.44) | LTA4H | |
| SCHEMBL8642321 | 0.76 | HSD17B10 (0.47) | LTA4H | |
| SCHEMBL8635939 | 0.74 | LTA4H (0.60) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |