Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689010 | 0.82 | PTGS2 (0.47) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8637341 | 0.81 | PTGS2 (0.70) | PTGS2PTGS1PDPK1 | |
| SCHEMBL6344807 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8640768 | 0.80 | PTGS2 (0.67) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8638828 | 0.80 | PTGS2 (0.65) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8691643 | 0.79 | PDPK1 (0.49) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8639323 | 0.78 | PTGS2 (0.51) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8637585 | 0.78 | PDPK1 (0.69) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8637765 | 0.78 | PDPK1 (0.50) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8641453 | 0.78 | PTGS2 (0.47) | PTGS2PTGS1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |