Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | PKM | P14618 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 2/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639346 | 0.91 | GRIN1 (0.55) | GRIN1GRIN2BMAPTPKMRAB9A | |
| SCHEMBL8641196 | 0.85 | GRIN1 (0.63) | GRIN1GRIN2BMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8557293 | 0.81 | MAPT (0.97) | GRIN1GRIN2BMAPTPKMRAB9A | |
| SCHEMBL7453184 | 0.81 | GRIN1 (1.00) | GRIN1GRIN2BMAPTPKMRAB9A | |
| SCHEMBL6368842 | 0.77 | MAPT (0.84) | GRIN1GRIN2BMAPTPKMRAB9A | |
| SCHEMBL8641842 | 0.75 | LTA4H (0.51) | MAPTRAB9AL3MBTL1LMNANPC1 | |
| SCHEMBL8640793 | 0.75 | NPC1 (0.65) | GRIN1GRIN2BMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27918353 | 0.75 | GRIN1 (0.73) | GRIN1GRIN2BMAPTPKMRAB9A | |
| SCHEMBL8948422 | 0.74 | NPC1 (0.71) | GRIN1GRIN2BMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8641659 | 0.72 | GRIN1 (0.66) | GRIN1GRIN2BMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |