Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.97 |
| ▸ | GAA | P10253 | 4/20 | 0.97 |
| ▸ | PKM | P14618 | 4/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.97 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.78 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.78 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453184 | 0.88 | GRIN1 (1.00) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL3762307 | 0.88 | MAPT (0.76) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL6368842 | 0.84 | MAPT (0.84) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL8973998 | 0.83 | POLB (0.71) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL27918353 | 0.81 | GRIN1 (0.73) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL4164831 | 0.81 | EGFR (0.76) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL8637099 | 0.81 | GRIN1 (0.67) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL4035159 | 0.81 | GAA (0.75) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL11931389 | 0.81 | GAA (0.66) | MAPTGAAPKMKDM4ETDP1 | |
| SCHEMBL17786373 | 0.81 | KMT2A (0.68) | MAPTGAAPKMKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |