Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052796 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8637047 | 0.85 | PTGS2 (0.63) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL7928751 | 0.85 | PTGS2 (0.66) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL6013964 | 0.83 | PTGS2 (0.72) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL7773921 | 0.83 | PTGS2 (0.65) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8525009 | 0.83 | PTGS2 (0.65) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8689078 | 0.82 | PTGS2 (0.61) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8165901 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8635925 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1ALDH1A1ABCB11 | |
| SCHEMBL8639180 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1ALDH1A1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |