Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640765 | 0.90 | PTGS1 (0.51) | PTGS2PDPK1PTGS1RXRANR1H2 | |
| SCHEMBL8652506 | 0.89 | PTGS2 (0.54) | PTGS2PDPK1PTGS1RXRANR1H2 | |
| SCHEMBL7135445 | 0.89 | PTGS2 (0.51) | PTGS2PDPK1PTGS1CYP2C9ALOX5 | |
| SCHEMBL8636828 | 0.88 | PDPK1 (0.61) | PTGS2PDPK1PTGS1CYP2C9ALOX5 | |
| SCHEMBL8351386 | 0.88 | PTGS2 (0.49) | PTGS2PDPK1PTGS1RXRANR1H2 | |
| SCHEMBL8641577 | 0.88 | PTGS2 (0.49) | PTGS2PDPK1PTGS1CYP2C9RXRA | |
| SCHEMBL8638028 | 0.87 | PDPK1 (0.52) | PTGS2PDPK1PTGS1CYP2C9RXRA | |
| SCHEMBL8640576 | 0.87 | PTGS2 (0.55) | PTGS2PDPK1PTGS1CA12CA2 | |
| SCHEMBL8638817 | 0.87 | PTGS2 (0.46) | PTGS2PDPK1PTGS1ALOX5RXRA | |
| SCHEMBL8639795 | 0.87 | PTGS2 (0.50) | PTGS2PDPK1PTGS1CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |