Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640765 | 0.89 | PTGS1 (0.51) | PTGS2PTGS1PDPK1ALDH1A1FFAR4 | |
| SCHEMBL8636828 | 0.87 | PDPK1 (0.61) | PTGS2PTGS1PDPK1CA12CA2 | |
| SCHEMBL8637656 | 0.87 | PTGS2 (0.48) | PTGS2PTGS1PDPK1CA12CA2 | |
| SCHEMBL8351386 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1PDPK1SMN1; SMN2MAPT | |
| SCHEMBL8641577 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1PDPK1MEN1KMT2A | |
| SCHEMBL8638817 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1PDPK1SMN1; SMN2MAPT | |
| SCHEMBL8421755 | 0.86 | MEN1 (0.47) | MEN1KMT2AALDH1A1PKMCA12 | |
| SCHEMBL8639795 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1PDPK1 | |
| SCHEMBL6514097 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1PDPK1MEN1KMT2A | |
| SCHEMBL8643571 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1PDPK1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |