SCHEMBL8637703

SCHEMBL8637703

Cc1c(C)c2c(c(C3CC(=O)CC(=O)C3)c1C)OC(C)(C)C2

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8876820 0.88 POLB (0.31) POLBMAPTKMT2ANPSR1TDP1
SCHEMBL8058623 0.73 GAA (0.32) MAPT
SCHEMBL12676491 0.73 MAPT (0.41) POLBMAPTKMT2ANPSR1TDP1
SCHEMBL8747110 0.71 ALDH1A1 (0.33) KMT2A
SCHEMBL8877720 0.70 POLB (0.40) POLBMAPTTDP1
SCHEMBL8877755 0.70 RAB9A (0.38) MAPTKMT2A
SCHEMBL8877762 0.70 RAB9A (0.38) MAPTKMT2A
SCHEMBL8074398 0.69 TP53 (0.32)
SCHEMBL8067839 0.69 KDM4E (0.37)
SCHEMBL8878032 0.68 RAB9A (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10053580-A None JP disclosed
JP-H1053580-A CYCLOHEXANE-1,3-DIONE DERIVATIVE AND ITS PRODUCTION KOREA RES INST OF CHEM TECHNOL 1998-02-24 JP disclosed
US-5631208-A Herbicidal cyclohexane-1,3-dione derivatives and their preparation process KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1997-05-20 US disclosed
WO-1994003443-A1 HERBICIDAL CYCLOHEXANE-1,3-DIONE DERIVATIVES AND THEIR PREPARATION PROCESS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1994-02-17 WO disclosed