Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400980 | 0.72 | HRH3 (0.44) | HRH3MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL7400975 | 0.71 | HDAC1 (0.44) | HRH3LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL27446148 | 0.71 | OPRD1 (0.44) | HRH3LMNARORCMAPTMAPK1 | |
| SCHEMBL8637900 | 0.71 | OPRD1 (0.42) | HRH3LMNATSHRSMN1; SMN2 | |
| SCHEMBL8635363 | 0.71 | SLC2A1 (0.45) | HRH3MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL8699932 | 0.71 | GAA (0.42) | HRH3TSHRMAPTKDM4EGAA | |
| SCHEMBL8637905 | 0.70 | ITGB3 (0.43) | HRH3LMNASMN1; SMN2 | |
| SCHEMBL45807 | 0.70 | KMT2A (0.47) | LMNATSHRKDM4EGAA | |
| SCHEMBL8635419 | 0.70 | SMN1; SMN2 (0.42) | HRH3MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL7329220 | 0.69 | SLC2A1 (0.45) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |