Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701648 | 0.94 | NPC1 (0.50) | ALDH1A1KMT2AKDM4EPOLBMMP8 | |
| SCHEMBL11900967 | 0.94 | MMP8 (0.49) | ALDH1A1KMT2AKDM4EPOLBMMP8 | |
| SCHEMBL6587934 | 0.92 | KMT2A (0.47) | ALDH1A1KMT2AKDM4EPOLBMMP8 | |
| SCHEMBL19502670 | 0.88 | MMP8 (0.54) | ALDH1A1KMT2APOLBMMP8TDP1 | |
| SCHEMBL23203481 | 0.87 | ALDH1A1 (0.43) | ALDH1A1KMT2AKDM4EPOLBMMP8 | |
| SCHEMBL28019865 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KMT2AKDM4EPOLBNPC1 | |
| SCHEMBL28019866 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KMT2AKDM4EPOLBNPC1 | |
| SCHEMBL28020287 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KMT2AKDM4EPOLBNPC1 | |
| SCHEMBL11900963 | 0.85 | KMT2A (0.50) | ALDH1A1KMT2AKDM4EPPARGPPARA | |
| SCHEMBL231669 | 0.84 | TSHR (0.47) | ALDH1A1KMT2AKDM4EPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643688-B1 | SUBSTITUTED (ARYLALKOXYBENZYL)AMINOPROPANAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-EPILEPTIC, NEUROPROTECTIVE AND ANTIDEPRESSANT AGENTS | PHARMACIA & UPJOHN SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| WO-1998020001-A1 | THIOPROLINE-CONTAINING INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |
| CN-1035938-C | Substituted (arylalkoxybenzyl) aminopropanamide derivatives, their preparation and use as anti-epileptic, neuroprotective and antidepressant agents | PHARMACIA FRAMITALIA CARLO ERB (IT) | 1997-09-24 | — | — | CN | disclosed |
| US-5446066-A | Antiepileptic, antidepressants, antispastic agent | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-08-29 | — | — | US | disclosed |
| CN-1104017-A | Substituted (arylalkoxybenzyl) aminopropanamide derivatives, their preparation and use as anti-epileptic, neuroprotective and antidepressant agents | ERBA FARMITALIA (IT) | 1995-06-21 | — | — | CN | disclosed |