Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.57 |
| ▸ | PPARG | P37231 | 4/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.51 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17807116 | 0.84 | LTA4H (0.61) | LTA4HPPARGPPARACALM1L3MBTL1 | |
| SCHEMBL11579600 | 0.81 | MAOB (0.59) | LTA4HPPARGPPARASLC6A2MAOA | |
| SCHEMBL24309913 | 0.81 | CA4 (0.43) | LTA4HSLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL507063 | 0.81 | CA4 (0.43) | LTA4HSLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL5684114 | 0.79 | LTA4H (0.65) | LTA4HPPARGPPARACALM1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL28234445 | 0.79 | POLB (0.42) | LTA4HSLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL8908541 | 0.78 | LTA4H (0.59) | LTA4HPPARGPPARACALM1L3MBTL1 | |
| SCHEMBL7052665 | 0.78 | CYP1A2 (0.58) | PPARGPPARATAAR1MAOACYP1A2 | |
| SCHEMBL23067917 | 0.78 | PPARG (0.45) | PPARGPPARATAAR1SLC6A4CYP2D6 | |
| SCHEMBL9487460 | 0.78 | LTA4H (0.52) | LTA4HPPARGPPARAMAOAACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |