SCHEMBL8638490

SCHEMBL8638490

C[C@@H](Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.59
CYP1A2 P05177 3/20 0.56
CYP2C9 P11712 3/20 0.56
CYP2C19 P33261 3/20 0.56
GAA P10253 1/20 0.56
PKM P14618 1/20 0.56
EPHX2 P34913 2/20 0.54
PPARG P37231 2/20 0.54
PPARA Q07869 2/20 0.54
FABP2 P12104 1/20 0.54
SLC22A12 Q96S37 1/20 0.54
MAP4K4 O95819 2/20 0.52
SRD5A2 P31213 1/20 0.52
TDP1 Q9NUW8 2/20 0.51
ELANE P08246 1/20 0.51
TSHR P16473 2/20 0.51
HTR2A P28223 2/20 0.51
HTR2C P28335 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8638497 1.00 HPGD (0.59) HPGDCYP1A2CYP2C9CYP2C19GAA
SCHEMBL2399722 0.91 CYP1A2 (0.65) CYP1A2CYP2C9CYP2C19GAAPKM
SCHEMBL117259 0.91 CYP1A2 (0.65) CYP1A2CYP2C9CYP2C19GAAPKM
SCHEMBL607372 0.91 CYP1A2 (0.65) CYP1A2CYP2C9CYP2C19GAAPKM
SCHEMBL27765434 0.90 CYP1A2 (0.62) CYP1A2CYP2C9CYP2C19GAAPKM
Hydrochloric Acid SCHEMBL11632943 0.90 CYP1A2 (0.62) CYP1A2CYP2C9CYP2C19GAAPKM
SCHEMBL20591019 0.90 CYP1A2 (0.62) CYP1A2CYP2C9CYP2C19GAAPKM
Ammonia Solution, Strong SCHEMBL28260028 0.90 CYP1A2 (0.62) CYP1A2CYP2C9CYP2C19GAAPKM
SCHEMBL12852977 0.86 CYP1A2 (0.69) HPGDCYP1A2CYP2C9CYP2C19GAA
SCHEMBL3217144 0.86 CYP1A2 (0.59) CYP1A2CYP2C9CYP2C19GAAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5801272-A Preparation of mixtures of (R)- and (S)-2-(4-alkanoylphenoxy)- or (R)- and (S)-2-(4-aroylphenoxy)propionic esters BASF AKTIENGESELLSCHAFT (DE) 1998-09-01 US disclosed
EP-0701547-B1 THE PREPARATION OF MIXTURES OF (R)- AND (S)-2-(4-ALKANOYLPHENOXY)- OR (R)- AND (S)-2-(4-AROYLPHENOXY)PROPIONIC ESTERS BASF AG (DE) 1998-07-29 EP disclosed