SCHEMBL8638732

SCHEMBL8638732

CO[Si](C)(c1ccccc1)[Si](C)(c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
CA4 P22748 2/20 0.35
POLB P06746 2/20 0.31
ALDH1A1 P00352 2/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
LTA4H P09960 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9466367 0.87 ESR1 (0.41) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8639620 0.83 ESR1 (0.38) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8642194 0.81 ESR1 (0.37) ESR1ESR2CA4POLBALDH1A1
SCHEMBL9684356 0.81 ESR1 (0.37) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8416106 0.81 ESR1 (0.37) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8415126 0.81 CA4 (0.40) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8415134 0.79 ESR1 (0.35) ESR1ESR2CA4POLB
SCHEMBL8412824 0.78 CA4 (0.42) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8642299 0.78 ESR1 (0.38) ESR1ESR2CA4POLBALDH1A1
SCHEMBL8642293 0.78 ESR1 (0.38) ESR1ESR2CA4POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641820-B1 Organosilicon polymer and process for the preparation thereof TOSHIBA SILICONE (JP) 1998-08-12 EP disclosed
US-5489662-A Process for the preparation of organosilicon polymer TOSHIBA SILICONE CO., LTD. (JP) 1996-02-06 US disclosed
EP-0641820-A1 Process for the preparation of organosilicon polymer TOSHIBA SILICONE CO., LTD. (JP) 1995-03-08 EP disclosed