Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8699436 | 0.80 | KMO (0.60) | MKNK1MKNK2F7F3MEN1 | |
| SCHEMBL8637967 | 0.79 | KMO (0.59) | MKNK1MKNK2GAASLC2A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL8705713 | 0.79 | KMO (0.58) | MKNK1MKNK2F7F3MEN1 | |
| SCHEMBL8639260 | 0.78 | MKNK1 (0.49) | MKNK1MKNK2SLC2A1 | |
| Hydrochloric Acid SCHEMBL8645959 | 0.75 | CSNK1A1 (0.46) | F10ROCK2ABL1 | |
| SCHEMBL27714168 | 0.74 | HDAC1 (0.61) | F7F3GAAROCK2CYP2C9 | |
| SCHEMBL8446220 | 0.74 | PLAU (0.48) | F2F10ROCK2 | |
| SCHEMBL19229958 | 0.74 | KMT2A (0.56) | MKNK1MKNK2SLC2A1CYP3A4CYP2A6 | |
| Hydrochloric Acid SCHEMBL27467353 | 0.72 | NAMPT (0.57) | F2GAALMNANPC1RAB9A | |
| SCHEMBL8690581 | 0.72 | MKNK1 (0.43) | MKNK1MKNK2LMNAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849775-A | Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5679712-A | ANTIARRHYTHMIA AGENTS, TREATMENT OF CARDIOVASCULAR, NERVOUS SYSTEM DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | disclosed |