Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.49 |
| ▸ | HTR7 | P34969 | 8/20 | 0.45 |
| ▸ | HTR2B | P41595 | 8/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637967 | 0.81 | KMO (0.59) | MKNK1MKNK2SLC2A1 | |
| SCHEMBL7814937 | 0.79 | KMO (0.63) | MKNK1MKNK2CHEK2 | |
| SCHEMBL8639249 | 0.78 | MKNK1 (0.47) | MKNK1MKNK2SLC2A1 | |
| Hydrochloric Acid SCHEMBL27404908 | 0.78 | KMO (0.61) | MKNK1MKNK2CHEK2 | |
| Hydrochloric Acid SCHEMBL7823972 | 0.78 | KMO (0.61) | MKNK1MKNK2CHEK2 | |
| SCHEMBL7915997 | 0.77 | SLC9A1 (0.48) | MKNK1MKNK2HTR7HTR2BDRD2 | |
| SCHEMBL19229958 | 0.76 | KMT2A (0.56) | MKNK1MKNK2SLC2A1 | |
| SCHEMBL12367001 | 0.75 | MKNK1 (0.43) | MKNK1MKNK2HTR7HTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL8645968 | 0.74 | CSNK1A1 (0.48) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL12366593 | 0.73 | MKNK1 (0.42) | MKNK1MKNK2HTR7HTR2BCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849775-A | Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5679712-A | ANTIARRHYTHMIA AGENTS, TREATMENT OF CARDIOVASCULAR, NERVOUS SYSTEM DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | disclosed |