Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.70 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 6/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406605 | 0.92 | SIGMAR1 (0.82) | SIGMAR1TMEM97ALDH1A1LTA4HDRD4 | |
| Hydrochloric Acid SCHEMBL7409008 | 0.91 | SIGMAR1 (0.80) | SIGMAR1TMEM97ALDH1A1LTA4HDRD4 | |
| SCHEMBL8644124 | 0.88 | TMEM97 (0.70) | SIGMAR1TMEM97LTA4HHTR1AHTR7 | |
| SCHEMBL7409069 | 0.87 | SIGMAR1 (0.82) | SIGMAR1TMEM97ALDH1A1LTA4HDRD4 | |
| SCHEMBL8638263 | 0.87 | TMEM97 (0.65) | SIGMAR1TMEM97ALDH1A1LTA4HHRH3 | |
| Hydrochloric Acid SCHEMBL7404802 | 0.86 | SIGMAR1 (0.80) | SIGMAR1TMEM97ALDH1A1LTA4HDRD4 | |
| SCHEMBL7408573 | 0.86 | SIGMAR1 (0.82) | SIGMAR1TMEM97ALDH1A1DRD4HRH3 | |
| Bromide SCHEMBL8169444 | 0.85 | SIGMAR1 (0.81) | SIGMAR1TMEM97ALDH1A1DRD4HRH3 | |
| SCHEMBL7404109 | 0.84 | SIGMAR1 (0.73) | SIGMAR1TMEM97ALDH1A1LTA4HDRD4 | |
| SCHEMBL7248846 | 0.83 | TMEM97 (0.71) | SIGMAR1TMEM97LTA4HHRH3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |