Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 6/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639262 | 0.87 | SIGMAR1 (0.70) | TMEM97SIGMAR1ALDH1A1LTA4HHTR1A | |
| SCHEMBL8637770 | 0.86 | TMEM97 (0.65) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL8641102 | 0.86 | HTR1A (0.67) | TMEM97SIGMAR1GAALTA4HHTR1A | |
| SCHEMBL7248846 | 0.80 | TMEM97 (0.71) | TMEM97SIGMAR1HTTLTA4HHRH3 | |
| SCHEMBL5888854 | 0.80 | TMEM97 (1.00) | TMEM97SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8644124 | 0.80 | TMEM97 (0.70) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| Bromide SCHEMBL7253600 | 0.79 | TMEM97 (0.69) | TMEM97SIGMAR1HTTLTA4HHRH3 | |
| SCHEMBL7406605 | 0.79 | SIGMAR1 (0.82) | TMEM97SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7409069 | 0.79 | SIGMAR1 (0.82) | TMEM97SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2158157 | 0.79 | KCNH2 (0.63) | TMEM97SIGMAR1HTTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |