Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 8/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641063 | 1.00 | CRACR2A (0.42) | CRACR2APTGS2PTGS1PDPK1F2 | |
| SCHEMBL8637272 | 0.99 | CRACR2A (0.43) | CRACR2APTGS2PTGS1PDPK1F2 | |
| SCHEMBL8644078 | 0.85 | PTGS2 (0.39) | CRACR2APTGS2PTGS1PDPK1F2 | |
| SCHEMBL8641446 | 0.82 | CRACR2A (0.40) | CRACR2APTGS2PTGS1PDPK1F2 | |
| SCHEMBL8637623 | 0.82 | PTGS2 (0.38) | PTGS2PTGS1PDPK1F2F10 | |
| SCHEMBL8635859 | 0.82 | PTGS2 (0.41) | PTGS2PTGS1PTGES2 | |
| SCHEMBL6013987 | 0.80 | PTGS2 (0.60) | PTGS2PTGS1PDPK1TSHR | |
| SCHEMBL6013942 | 0.80 | PTGS2 (0.60) | PTGS2PTGS1PDPK1TSHR | |
| SCHEMBL6013977 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1PDPK1TSHR | |
| SCHEMBL8023576 | 0.77 | PTGS2 (0.62) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |