Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.65 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637650 | 0.92 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL9014927 | 0.92 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8637676 | 0.92 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8639018 | 0.91 | PTGS2 (0.55) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8637585 | 0.91 | PDPK1 (0.69) | PTGS2PTGS1PDPK1CYP2C9 | |
| SCHEMBL8640768 | 0.90 | PTGS2 (0.67) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL5694290 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1PDPK1CYP2C9 | |
| SCHEMBL8641581 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8643577 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1PDPK1CYP2C9 | |
| SCHEMBL8637364 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1PDPK1RXRANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-11246940-B2 | Peptides whose uptake in cells is controllable | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-02-15 | — | — | US | disclosed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | disclosed |
| EP-0731795-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |