Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.79 |
| ▸ | HTR1B | P28222 | 5/20 | 0.79 |
| ▸ | DRD2 | P14416 | 2/20 | 0.79 |
| ▸ | HTR2C | P28335 | 2/20 | 0.79 |
| ▸ | HRH1 | P35367 | 2/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.79 |
| ▸ | MLNR | O43193 | 1/20 | 0.79 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.79 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.79 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.79 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.79 |
| ▸ | MAOA | P21397 | 1/20 | 0.79 |
| ▸ | CNR1 | P21554 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150997 | 0.93 | KCNH2 (0.75) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL1135593 | 0.92 | HTR1A (0.86) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| Sertindole SCHEMBL112092 | 0.88 | KCNH2 (1.00) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8642590 | 0.88 | HTR1A (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| Sertindole SCHEMBL29360085 | 0.88 | KCNH2 (1.00) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8640337 | 0.88 | HTR1A (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8642980 | 0.88 | HTR1A (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| Sertindole SCHEMBL28600134 | 0.88 | KCNH2 (0.98) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8640447 | 0.87 | HTR1A (0.78) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL6581419 | 0.87 | DRD2 (1.00) | HTR1AHTR1BDRD2HTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575430-B1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| EP-0533824-B1 | PIPERIDYL-SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 1994-11-09 | — | — | EP | disclosed |