SCHEMBL8640652

SCHEMBL8640652

COC(=O)/C=C\C(=O)OCC(C)O

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 0.54
KEAP1 Q14145 1/20 0.54
NFE2L2 Q16236 1/20 0.54
TSHR P16473 2/20 0.45
GFPT1 Q06210 1/20 0.40
MAPT P10636 3/20 0.39
ATM Q13315 1/20 0.38
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
JAK2 O60674 1/20 0.33
GAA P10253 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HPGD P15428 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9618418 1.00 HCAR2 (0.54) HCAR2KEAP1NFE2L2TSHRGFPT1
SCHEMBL8463070 1.00 HCAR2 (0.54) HCAR2KEAP1NFE2L2TSHRGFPT1
SCHEMBL4444141 0.91 TSHR (0.52) HCAR2KEAP1NFE2L2TSHRMAPT
SCHEMBL2808160 0.91 TSHR (0.52) HCAR2KEAP1NFE2L2TSHRMAPT
SCHEMBL2465097 0.91 TSHR (0.52) HCAR2KEAP1NFE2L2TSHRMAPT
SCHEMBL17324979 0.85 TSHR (0.57) HCAR2KEAP1NFE2L2TSHRGFPT1
SCHEMBL17048348 0.85 HCAR2 (0.56) HCAR2KEAP1NFE2L2TSHRGFPT1
SCHEMBL17048350 0.85 HCAR2 (0.56) HCAR2KEAP1NFE2L2TSHRGFPT1
SCHEMBL3439443 0.84 TSHR (0.47) HCAR2KEAP1NFE2L2TSHRMAPT
SCHEMBL8639055 0.83 HCAR2 (0.57) HCAR2TSHRMAPTATMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661477-B2 Star-shaped poly(propylene fumarate) copolymers for 3D printing applications THE UNIVERSITY OF AKRON (US) 2023-05-30 US disclosed
EP-0856016-A1 UNSATURATED HYDROXY DIESTER COPOLYMERS AND THEIR USE IN COATING COMPOSITIONS PPG INDUSTRIES, INC. (US) 1998-08-05 EP disclosed
WO-1997013797-A1 UNSATURATED HYDROXY DIESTER COPOLYMERS AND THEIR USE IN COATING COMPOSITIONS PPG INDUSTRIES, INC. (US) 1997-04-17 WO disclosed
US-5612416-A PROTECTIVE COATINGS FORMED FROM HYDROXY GROUP REACTIVE CURING AGENTS PPG INDUSTRIES, INC. (US) 1997-03-18 US disclosed