Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429885 | 0.91 | TSHR (0.67) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL317108 | 0.91 | TSHR (0.67) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL317107 | 0.91 | TSHR (0.67) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL28757749 | 0.89 | TSHR (0.64) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL19699816 | 0.88 | HCAR2 (0.52) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL19699814 | 0.88 | HCAR2 (0.52) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL18418525 | 0.86 | HCAR2 (0.50) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL9618418 | 0.85 | HCAR2 (0.54) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL8640652 | 0.85 | HCAR2 (0.54) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL8463070 | 0.85 | HCAR2 (0.54) | TSHRHCAR2KEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9795471-B2 | Polymer-tissue hybrid biomaterials and methods of making and using same | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2017-10-24 | — | — | US | disclosed |
| US-20160089476-A1 | POLYMER-TISSUE HYBRID BIOMATERIALS AND METHODS OF MAKING AND USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-31 | — | — | US | disclosed |
| US-20150353666-A1 | POLYMERS POLYMERIZED FROM AT LEAST FOUR MONOMERS, AND COMPOSITIONS AND USES THEREOF | ISP INVESTMENTS INS. (US) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353666-A1 | POLYMERS POLYMERIZED FROM AT LEAST FOUR MONOMERS, AND COMPOSITIONS AND USES THEREOF | ADSL, MMAB, ACMSD | TSHR 4761/4885HCAR2 1642/4885KEAP1 4194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.