SCHEMBL8640745

SCHEMBL8640745

O=C(Cl)C(=O)CCCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.64
HDAC3 O15379 3/20 0.64
HDAC2 Q92769 3/20 0.64
HDAC8 Q9BY41 3/20 0.64
HDAC6 Q9UBN7 3/20 0.64
HDAC5 Q9UQL6 3/20 0.64
HDAC4 P56524 2/20 0.64
HDAC7 Q8WUI4 2/20 0.64
HDAC10 Q969S8 2/20 0.64
HDAC11 Q96DB2 2/20 0.64
HDAC9 Q9UKV0 2/20 0.64
MAPK1 P28482 1/20 0.64
ADRA1A P35348 1/20 0.64
SLC6A3 Q01959 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
PLAAT3 P53816 7/20 0.59
PLAAT5 Q96KN8 7/20 0.59
PLAAT2 Q9NWW9 7/20 0.59
PLAAT4 Q9UL19 7/20 0.59
NPC1 O15118 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29256115 0.92 MAPT (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL11141595 0.88 KEAP1 (0.61) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL5566614 0.83 HDAC1 (0.69) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL61491 0.83 HDAC1 (0.69) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL710419 0.83 HDAC1 (0.69) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL27538484 0.82 HDAC1 (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL11208598 0.81 HDAC1 (0.60) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL6010223 0.80 HDAC1 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL21219015 0.79 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL1716 0.79 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665960-B1 IMAGING MEDIUM AND PROCESS POLAROID CORP (US) 1998-08-19 EP disclosed
US-5578424-A EXPOSING A MIXTURE OF AN ACID PRECURSOR AND A DYE TO ACTINIC RADIATION TO DECOMPOSE PRECURSOR POLAROID CORPORATION (US) 1996-11-26 US disclosed
EP-0665961-B1 IMAGING MEDIUM AND PROCESS POLAROID CORP (US) 1996-10-02 EP disclosed
US-5534388-A SUPERACID PRECURSOR IS EXPOSED TO ACTINIC RADIATION TO GENERATE SUPERACID; COLORIMETRIC ANALYSIS POLAROID CORPORATION (US) 1996-07-09 US disclosed
US-5453345-A Imaging medium POLAROID CORPORATION (US) 1995-09-26 US disclosed
US-5445917-A Superacid precursor to catalyze thermal decomposition of secondary acid generator, such as squaric acid and oxalic acid derivatives; effecting color change in imaging process POLAROID CORPORATION (US) 1995-08-29 US disclosed
EP-0665961-A1 IMAGING MEDIUM AND PROCESS. POLAROID CORP (US) 1995-08-09 EP disclosed
EP-0665960-A1 IMAGING MEDIUM AND PROCESS POLAROID CORPORATION (US) 1995-08-09 EP disclosed
US-5395736-A Exposing superoxide precursor to actinic radiation, generating superacid, mixing with oxalic acid diester, heating POLAROID CORPORATION (US) 1995-03-07 US disclosed
WO-1994010607-A1 IMAGING MEDIUM AND PROCESS POLAROID CORPORATION (US) 1994-05-11 WO disclosed
WO-1994010606-A1 IMAGING MEDIUM AND PROCESS POLAROID CORPORATION (US) 1994-05-11 WO disclosed