SCHEMBL710419

SCHEMBL710419

O=C(O)C(=O)CCCc1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.69
HDAC3 O15379 3/20 0.69
HDAC2 Q92769 3/20 0.69
HDAC8 Q9BY41 3/20 0.69
HDAC6 Q9UBN7 3/20 0.69
HDAC5 Q9UQL6 3/20 0.69
HDAC4 P56524 2/20 0.69
HDAC7 Q8WUI4 2/20 0.69
HDAC10 Q969S8 2/20 0.69
HDAC11 Q96DB2 2/20 0.69
HDAC9 Q9UKV0 2/20 0.69
MAPK1 P28482 1/20 0.69
ADRA1A P35348 1/20 0.69
SLC6A3 Q01959 1/20 0.69
SMN1; SMN2 Q16637 1/20 0.69
PLAAT3 P53816 5/20 0.62
PLAAT5 Q96KN8 5/20 0.62
PLAAT2 Q9NWW9 5/20 0.62
PLAAT4 Q9UL19 5/20 0.62
NPC1 O15118 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3270086 0.94 MAPT (0.68) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL8511630 0.92 MAPT (0.71) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL5566614 0.87 HDAC1 (0.69) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL258545 0.86 KEAP1 (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL10352043 0.84 KEAP1 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL8640745 0.83 HDAC1 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL6010223 0.83 HDAC1 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL3884738 0.83 HDAC1 (0.69) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL3884742 0.83 HDAC1 (0.69) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL5674267 0.82 HDAC1 (0.75) HDAC1HDAC3HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2822682-B1 MICROCAPSULES AND USES THEREOF FIRMENICH & CIE (CH) 2017-04-26 EP claimed
US-5371014-A Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1994-12-06 US claimed
CN-112708612-B Redox enzyme electrode for enzyme electrocatalytic reduction, preparation method thereof and enzyme electrocatalytic reactor 厦门大学 2025-02-11 CN disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
CN-110607289-B Amino acid dehydrogenase and application thereof 厦门大学 2021-07-09 CN disclosed
CN-112708612-A Oxidoreductase electrode for enzyme electrocatalytic reduction, preparation method thereof and enzyme electric reactor thereof 厦门大学 2021-04-27 CN disclosed
CN-110592037-B Phenylalanine dehydrogenase for catalyzing and preparing unnatural amino acid and application thereof 厦门大学 2021-03-30 CN disclosed
CN-107231807-B Genetically modified phenylpyruvic acid decarboxylase, preparation method and application thereof 陶氏环球技术有限责任公司 2021-03-16 CN disclosed
EP-3230462-B1 GENETICALLY MODIFIED PHENYLPYRUVATE DECARBOXYLASE, PROCESSES TO PREPARE, AND USES THEREOF DOW GLOBAL TECHNOLOGIES LLC (US) 2020-04-08 EP disclosed
CN-110607289-A Amino acid dehydrogenase and application thereof 厦门大学 2019-12-24 CN disclosed
US-4808713-A Anthypertensive pyridazo [1,2-a][1,2]diazepines HOFFMAN-LA ROCHE INC. (US) 1989-02-28 US disclosed
US-4772701-A Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihypertensives HOFFMANN-LA ROCHE INC. (US) 1988-09-20 US disclosed
US-4658024-A Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives HOFFMANN-LA ROCHE INC. (US) 1987-04-14 US disclosed
US-4576753-A MICROBIOCIDES, ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1986-03-18 US disclosed
US-4512924-A HYPOTENSIVE AGENTS HOFFMANN-LA ROCHE INC. (US) 1985-04-23 US disclosed
US-4472309-A ANTIMICROBIAL FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-09-18 US disclosed
EP-0094095-A2 Bicyclic carboxylic acids and their alkyl and aralkyl esters F. HOFFMANN-LA ROCHE AG (CH) 1983-11-16 EP disclosed
US-4304718-A ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-12-08 US disclosed
US-4181800-A ANTIBIOTICS FROM SUBSTITUTED PERHYDRO-S-TRIAZINES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-01-01 US disclosed