Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | LTA4H | P09960 | 6/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375479 | 0.91 | TMEM97 (0.55) | TMEM97SIGMAR1LTA4HATMHTR1A | |
| SCHEMBL7378007 | 0.91 | LTA4H (0.48) | TMEM97SIGMAR1LTA4HDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL7417600 | 0.90 | TMEM97 (0.54) | TMEM97SIGMAR1LTA4HATMHTR1A | |
| Hydrochloric Acid SCHEMBL7522283 | 0.90 | LTA4H (0.47) | TMEM97SIGMAR1LTA4HDRD2HTR2A | |
| SCHEMBL7379283 | 0.85 | MAOB (0.46) | TMEM97SIGMAR1LTA4HHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7403695 | 0.84 | TMEM97 (0.57) | TMEM97SIGMAR1LTA4HATMHTR1A | |
| SCHEMBL7400333 | 0.83 | TMEM97 (0.56) | TMEM97SIGMAR1LTA4HATMHTR1A | |
| SCHEMBL8637801 | 0.83 | TMEM97 (0.56) | TMEM97SIGMAR1LTA4HHTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL7375791 | 0.82 | LTA4H (0.46) | TMEM97SIGMAR1LTA4HATMHTR1A | |
| SCHEMBL8644124 | 0.82 | TMEM97 (0.70) | TMEM97SIGMAR1LTA4HHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |