Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640943 | 0.83 | TMEM97 (0.59) | TMEM97SIGMAR1LTA4HHTR1ASLC6A4 | |
| SCHEMBL8641102 | 0.80 | HTR1A (0.67) | TMEM97SIGMAR1LTA4HHTR1ASLC6A4 | |
| SCHEMBL1333847 | 0.79 | KCNH2 (0.67) | SIGMAR1KCNH2 | |
| SCHEMBL8644124 | 0.78 | TMEM97 (0.70) | TMEM97SIGMAR1LTA4HHTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL1332072 | 0.78 | KCNH2 (0.69) | SIGMAR1KCNH2 | |
| SCHEMBL7032506 | 0.77 | SIGMAR1 (0.75) | SIGMAR1KCNH2 | |
| SCHEMBL21780869 | 0.77 | TMEM97 (0.63) | TMEM97SIGMAR1LTA4HHTR1AKCNH2 | |
| Hydrochloric Acid SCHEMBL1333883 | 0.76 | KCNH2 (0.76) | SIGMAR1KCNH2 | |
| SCHEMBL8639262 | 0.76 | SIGMAR1 (0.70) | TMEM97SIGMAR1LTA4HHTR1ASLC6A4 | |
| SCHEMBL7375479 | 0.75 | TMEM97 (0.55) | TMEM97SIGMAR1LTA4HHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |