Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.89 |
| ▸ | LTA4H | P09960 | 7/20 | 0.83 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.69 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.69 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | NPY1R | P25929 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398931 | 0.97 | HRH3 (0.89) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL7397621 | 0.96 | HRH3 (0.86) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL7142387 | 0.95 | HRH3 (0.97) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL8637452 | 0.94 | HRH3 (1.00) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL11258501 | 0.91 | LTA4H (0.83) | HRH3LTA4HKCNH2HRH4KDM4E | |
| SCHEMBL7140970 | 0.91 | LTA4H (1.00) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL7141103 | 0.89 | LTA4H (1.00) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL7133844 | 0.89 | LTA4H (1.00) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL7397639 | 0.88 | LTA4H (0.78) | HRH3LTA4HKCNH2HRH4KDM4E | |
| SCHEMBL491672 | 0.87 | HRH3 (0.79) | HRH3LTA4HKCNH2HRH4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |