Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8640891 | 0.99 | HPSE (0.40) | HPSEDDB1CRBNGRIN1GRIN2A | |
| SCHEMBL8644567 | 0.80 | HTR3A (0.41) | SLC6A4SLC6A3KDM1ASLC6A9 | |
| Hydrochloric Acid SCHEMBL8643226 | 0.79 | HTR3A (0.40) | SLC6A4SLC6A3KDM1ASLC6A9 | |
| SCHEMBL19559433 | 0.72 | DDB1 (0.43) | HPSEDDB1CRBNALDH1A1TSHR | |
| SCHEMBL16885997 | 0.72 | DDB1 (0.42) | HPSEDDB1CRBNGRIN1GRIN2A | |
| SCHEMBL20041908 | 0.71 | DDB1 (0.44) | HPSEDDB1CRBNALDH1A1TSHR | |
| SCHEMBL19559384 | 0.71 | DDB1 (0.44) | HPSEDDB1CRBNALDH1A1TSHR | |
| SCHEMBL5691645 | 0.67 | DDB1 (0.40) | DDB1CRBNALDH1A1TSHRMAOA | |
| SCHEMBL164122 | 0.66 | MEN1 (0.59) | SLC6A4SLC6A3MAOAKDM1AMAOB | |
| SCHEMBL6181098 | 0.66 | MEN1 (0.59) | SLC6A4SLC6A3MAOAKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667860-B1 | AZA SPIRO ALKANES DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1998-08-19 | — | — | EP | claimed |
| EP-0667860-B1 | AZA SPIRO ALKANES DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1998-08-19 | — | — | EP | disclosed |
| US-5610161-A | 1-AZASPIROALKANE DERIVATIVES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS; EATING DISORDERS | THE BOOTS COMPANY PLC (GB) | 1997-03-11 | — | — | US | disclosed |
| EP-0667860-A1 | AZA SPIRO ALKANES DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011346-A1 | AZA SPIRO ALKANES DERIVATIVES AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | disclosed |