Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638267 | 0.86 | HRH3 (0.44) | HRH3KDM4EALDH1A1TRPM8USP2 | |
| SCHEMBL8641777 | 0.80 | HRH3 (0.57) | HRH3KDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8637301 | 0.80 | SMN1; SMN2 (0.43) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8641796 | 0.80 | FFAR1 (0.50) | HRH3OPRM1 | |
| SCHEMBL8640497 | 0.77 | SPHK2 (0.50) | HRH3HPGDKDM4EALDH1A1POLB | |
| SCHEMBL8639328 | 0.77 | HRH3 (0.51) | HRH3KDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8637354 | 0.76 | SPHK2 (0.47) | HRH3POLBMCHR1 | |
| SCHEMBL8637785 | 0.76 | SCN3A (0.53) | SMN1; SMN2 | |
| SCHEMBL7246918 | 0.76 | CARM1 (0.40) | MCHR1SMN1; SMN2 | |
| SCHEMBL8640809 | 0.76 | HRH3 (0.47) | HRH3KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |