Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637354 | 0.87 | SPHK2 (0.47) | HRH3SPHK2SPHK1TDP1MAOA | |
| SCHEMBL8644163 | 0.82 | SPHK2 (0.53) | HRH3SPHK2SPHK1MAOAMAOB | |
| SCHEMBL8641777 | 0.81 | HRH3 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL8642201 | 0.80 | HRH3 (0.44) | SMN1; SMN2ALDH1A1HRH3KDM4E | |
| SCHEMBL8641796 | 0.78 | FFAR1 (0.50) | KMT2AHRH3MAOB | |
| SCHEMBL8636128 | 0.78 | MAOB (0.56) | SPHK2SPHK1MAOAMAOB | |
| SCHEMBL8641664 | 0.78 | FAAH (0.45) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8640497 | 0.78 | SPHK2 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL8639328 | 0.78 | HRH3 (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL8637785 | 0.77 | SCN3A (0.53) | SMN1; SMN2SPHK2SPHK1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |