Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640497 | 0.90 | SPHK2 (0.50) | HRH3MAOBNPC1SMN1; SMN2MEN1 | |
| SCHEMBL8640526 | 0.89 | LMNA (0.48) | HRH3MAOBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL8640809 | 0.89 | HRH3 (0.47) | HRH3MAOBNPC1SMN1; SMN2MEN1 | |
| SCHEMBL8641777 | 0.88 | HRH3 (0.57) | HRH3NPC1SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8641796 | 0.80 | FFAR1 (0.50) | HRH3MAOBKMT2A | |
| SCHEMBL8644163 | 0.80 | SPHK2 (0.53) | HRH3MAOBSPHK1SPHK2 | |
| SCHEMBL8636128 | 0.80 | MAOB (0.56) | MAOBSPHK1SPHK2 | |
| SCHEMBL8637301 | 0.78 | SMN1; SMN2 (0.43) | HRH3MAOBSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8641764 | 0.77 | HRH3 (0.50) | HRH3SIGMAR1SPHK1SPHK2 | |
| SCHEMBL8637785 | 0.77 | SCN3A (0.53) | MAOBNPC1SMN1; SMN2PARP10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |