Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 13/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134727 | 0.67 | DRD2 (0.36) | KDM4EALDH1A1CYP2D6 | |
| SCHEMBL6129775 | 0.66 | OPRM1 (0.39) | — | |
| SCHEMBL25051426 | 0.66 | OPRM1 (0.39) | — | |
| SCHEMBL14833411 | 0.64 | DRD2 (0.38) | — | |
| SCHEMBL3124211 | 0.63 | OPRM1 (0.34) | LTA4HKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL24998567 | 0.63 | MEN1 (0.41) | KMT2AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL14058149 | 0.63 | OPRL1 (0.34) | — | |
| SCHEMBL25000121 | 0.62 | CYP2D6 (0.43) | KMT2AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL31105377 | 0.62 | CYP2D6 (0.43) | KMT2AMEN1ALDH1A1CYP2D6 | |
| SCHEMBL12672699 | 0.62 | MEN1 (0.45) | KMT2AMEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |