SCHEMBL8644443

SCHEMBL8644443

O=c1cc(Oc2ccccc2)c2ccccc2o1

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KCNA3 P22001 2/20 0.66
▸ CA12 O43570 2/20 0.55
▸ CA1 P00915 2/20 0.55
▸ CA9 Q16790 2/20 0.55
▸ NPC1 O15118 1/20 0.54
▸ POLB P06746 1/20 0.54
▸ RAB9A P51151 1/20 0.54
▸ L3MBTL1 Q9Y468 1/20 0.54
▸ NQO1 P15559 1/20 0.53
▸ MEN1 O00255 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ TP53 P04637 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ PTGS2 P35354 1/20 0.47
▸ MAOB P27338 1/20 0.47
▸ HPGD P15428 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15842925 0.81 KCNA3 (0.67) KCNA3CA12CA1CA9NPC1
SCHEMBL17787234 0.79 NQO1 (0.61) KCNA3CA12CA1CA9L3MBTL1
SCHEMBL1627582 0.79 CYP2A6 (0.64) KCNA3CA12CA1CA9NPC1
SCHEMBL24237031 0.79 KCNA3 (0.97) KCNA3CA12CA1CA9MAOB
SCHEMBL31120088 0.77 HDAC1 (0.48) KCNA3CA12CA1CA9MEN1
SCHEMBL15842820 0.76 CA12 (0.55) KCNA3CA12CA1CA9L3MBTL1
SCHEMBL31236780 0.76 CA12 (0.55) KCNA3CA12CA1CA9L3MBTL1
SCHEMBL11452110 0.76 KCNA3 (0.65) KCNA3CA12CA1CA9NPC1
SCHEMBL15864643 0.75 NQO1 (0.56) KCNA3CA12CA1CA9NPC1
SCHEMBL15843118 0.75 PTGS2 (0.59) KCNA3CA12CA1CA9NQO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115304573-A Synthetic method of 4-aromatic ether coumarin derivative 山东达冠医药科技有限公司 2022-11-08 — — CN claimed
US-9127092-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2015-09-08 — — US claimed
US-20140187725-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2014-07-03 — — US claimed
JP-8073304-A — — None — — JP disclosed
US-12129260-B2 Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents King Faisal University (SA) 2024-10-29 — — US disclosed
US-20240279235-A1 BENZOFURO[3,2-C]CHROMEN-6-ONE COMPOUNDS AS ANTIBACTERIAL AGENTS King Faisal University (SA) 2024-08-22 — — US disclosed
US-11976080-B1 Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents King Faisal University (SA) 2024-05-07 — — US disclosed
US-11802130-B1 Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents King Faisal University (SA) 2023-10-31 — — US disclosed
CN-115304573-A Synthetic method of 4-aromatic ether coumarin derivative 山东达冠医药科技有限公司 2022-11-08 — — CN disclosed
CN-115304573-A Synthetic method of 4-aromatic ether coumarin derivative 山东达冠医药科技有限公司 2022-11-08 — — CN disclosed
US-9127092-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2015-09-08 — — US disclosed
US-5759959-A SELECTIVE CONTROL OF MONOCOTYLEDENOUS WEEDS IN THE PRESENCE OF A CROP PLANT AMERICAN CYANAMID COMPANY (US) 1998-06-02 — — US disclosed
US-5681968-A EFFECTIVE TO CONTROL GRASS AND OTHER MONOCOTOLYDENOUS WEEDS AMERICAN CYANAMID COMPANY (US) 1997-10-28 — — US disclosed
US-5681968-A EFFECTIVE TO CONTROL GRASS AND OTHER MONOCOTOLYDENOUS WEEDS AMERICAN CYANAMID COMPANY (US) 1997-10-28 — — US disclosed
US-5563280-A CONTROLLING MONOCOTYLEDENOUS WEEDS IN CROPS AMERICAN CYANAMID CO. (US) 1996-10-08 — — US disclosed
US-5563280-A CONTROLLING MONOCOTYLEDENOUS WEEDS IN CROPS AMERICAN CYANAMID CO. (US) 1996-10-08 — — US disclosed
CN-1119188-A 4-phenoxycoumarins as herbicidal agents AMERICAN CYANAMID CO (US) 1996-03-27 — — CN disclosed
JP-H0873304-A 4-PHENOXYCOUMARINS AS HERBICIDE AMERICAN CYANAMID CO 1996-03-19 — — JP disclosed
EP-0694257-A1 4-Phenoxycoumarins and thio derivatives thereof, their preparation and use as herbicides AMERICAN CYANAMID COMPANY (US) 1996-01-31 — — EP disclosed
EP-0694257-A1 4-Phenoxycoumarins and thio derivatives thereof, their preparation and use as herbicides AMERICAN CYANAMID COMPANY (US) 1996-01-31 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240279235-A1 BENZOFURO[3,2-C]CHROMEN-6-ONE COMPOUNDS AS ANTIBACTERIAL AGENTS TOP2A, TOP2B, TOP1 KCNA3 2931/4885CA12 4356/4885CA1 4789/4885
US-11802130-B1 Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents TOP2A, TOP2B, TOP1 KCNA3 2931/4885CA12 4356/4885CA1 4789/4885
US-11976080-B1 Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents TOP2A, TOP2B, TOP1 KCNA3 2931/4885CA12 4356/4885CA1 4789/4885
US-12129260-B2 Benzofuro[3,2-c]chromen-6-one compounds as antibacterial agents TOP2A, TOP2B, TOP1 KCNA3 2931/4885CA12 4356/4885CA1 4789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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