Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 5/20 | 0.58 |
| ▸ | HTR1D | P28221 | 4/20 | 0.58 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7540979 | 0.94 | HTR1B (0.57) | HTR6HTR1BHTR1DNR2E1EGFR | |
| SCHEMBL9336211 | 0.81 | HTR1B (0.63) | HTR6HTR1BHTR1DNR2E1EGFR | |
| SCHEMBL2321122 | 0.81 | HTR1B (0.59) | HTR6HTR1BHTR1DNR2E1EGFR | |
| SCHEMBL8643978 | 0.81 | MAPT (0.56) | HTR6HTR1BHTR1DNR2E1EGFR | |
| SCHEMBL8643056 | 0.80 | EGFR (0.44) | HTR6HTR1BHTR1DNR2E1EGFR | |
| Hydrochloric Acid SCHEMBL7026693 | 0.80 | HTR1B (0.58) | HTR6HTR1BHTR1DNR2E1EGFR | |
| Oxalic Acid SCHEMBL7540871 | 0.78 | HTR1B (0.60) | HTR6HTR1BHTR1DNR2E1EGFR | |
| SCHEMBL8531274 | 0.78 | HTR6 (0.41) | HTR6HTR1BHTR1DHTR1AHTR1F | |
| SCHEMBL9334201 | 0.77 | HTR1B (0.69) | HTR6HTR1BHTR1DNR2E1EGFR | |
| Oxalic Acid SCHEMBL8648619 | 0.77 | HTR1B (0.43) | HTR6HTR1BHTR1DNR2E1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603432-B1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1998-10-21 | — | — | EP | claimed |
| EP-0591280-B1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-09 | — | — | EP | claimed |
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | claimed |
| EP-0591280-A1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000086-A1 | USE OF TETRAHYDROCARBAZONE DERIVATIVES AS 5HT1 RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | claimed |