Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 4/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | ATP4A | P20648 | 9/20 | 0.49 |
| ▸ | ATP4B | P51164 | 9/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645400 | 1.00 | HRH2 (0.50) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8651841 | 0.90 | ATP4A (0.51) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8651839 | 0.90 | ATP4A (0.51) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8645429 | 0.90 | ATP4A (0.53) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8645433 | 0.90 | ATP4A (0.53) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8647612 | 0.90 | ATP4A (0.47) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8647609 | 0.90 | ATP4A (0.47) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL9092260 | 0.89 | HRH2 (0.55) | HRH2HRH4ATP4AATP4BPRMT6 | |
| SCHEMBL9093209 | 0.88 | ATP4A (0.47) | HRH2HRH4DRD2DRD3HRH3 | |
| SCHEMBL8659301 | 0.88 | ATP4A (0.56) | HRH2HRH4DRD2DRD3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545376-A1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | claimed |
| EP-0545376-B1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5532258-A | ANTIULCER AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0545376-A1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |