Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 10/20 | 0.47 |
| ▸ | ATP4B | P51164 | 10/20 | 0.47 |
| ▸ | HRH2 | P25021 | 4/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647612 | 1.00 | ATP4A (0.47) | ATP4AATP4BHRH2HRH4KDM4E | |
| SCHEMBL8643845 | 0.95 | ATP4A (0.48) | ATP4AATP4BHRH2HRH4NPC1 | |
| SCHEMBL8643846 | 0.95 | ATP4A (0.48) | ATP4AATP4BHRH2HRH4NPC1 | |
| Hydrochloric Acid SCHEMBL8651698 | 0.94 | ATP4A (0.49) | ATP4AATP4BHRH2HRH4NPC1 | |
| Hydrochloric Acid SCHEMBL8651701 | 0.94 | ATP4A (0.49) | ATP4AATP4BHRH2HRH4NPC1 | |
| SCHEMBL8647623 | 0.91 | ATP4A (0.46) | ATP4AATP4BHRH2HRH4NPC1 | |
| SCHEMBL8647618 | 0.91 | ATP4A (0.46) | ATP4AATP4BHRH2HRH4NPC1 | |
| SCHEMBL8645400 | 0.90 | HRH2 (0.50) | ATP4AATP4BHRH2HRH4KDM4E | |
| SCHEMBL8645397 | 0.90 | HRH2 (0.50) | ATP4AATP4BHRH2HRH4KDM4E | |
| SCHEMBL8647632 | 0.89 | ATP4A (0.45) | ATP4AATP4BHRH2HRH4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545376-B1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5532258-A | ANTIULCER AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0545376-A1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |