Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 6/20 | 0.48 |
| ▸ | PPARD | Q03181 | 6/20 | 0.48 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL11661675 | 1.00 | GPR84 (0.56) | GPR84FFAR1FFAR4LMNACAMK2A | |
| Sebacic Acid SCHEMBL11657763 | 0.98 | GPR84 (0.61) | GPR84FFAR1FFAR4LMNACAMK2A | |
| Adipic Acid SCHEMBL6402459 | 0.92 | LMNA (0.65) | GPR84FFAR1FFAR4LMNAABCC4 | |
| Adipic Acid SCHEMBL874846 | 0.92 | LMNA (0.65) | GPR84FFAR1FFAR4LMNAABCC4 | |
| Propene SCHEMBL7058438 | 0.90 | TSHR (0.67) | GPR84FFAR1FFAR4LMNAABCC4 | |
| Azelaic Acid SCHEMBL4945040 | 0.90 | TSHR (0.67) | GPR84FFAR1FFAR4LMNAABCC4 | |
| Propene SCHEMBL7052579 | 0.90 | TSHR (0.67) | GPR84FFAR1FFAR4LMNAABCC4 | |
| Succinic Acid SCHEMBL6421948 | 0.90 | EGLN1 (0.50) | GPR84FFAR1FFAR4LMNACAMK2A | |
| Sebacic Acid SCHEMBL7053358 | 0.90 | TSHR (0.67) | GPR84FFAR1FFAR4LMNAABCC4 | |
| Sebacic Acid SCHEMBL7057259 | 0.90 | TSHR (0.67) | GPR84FFAR1FFAR4LMNAABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011510-A1 | METHOD FOR PRODUCING FUNCTIONALIZED POLYESTERS | HENKEL AG & CO. KGAA (DE) | 2019-01-17 | — | — | WO | disclosed |
| EP-0611809-B1 | Latex paints with microemulsion modifier and process for their preparation | GLIDDEN CO (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5470906-A | Polyurethane or polyester coating and solvent | THE GLIDDEN COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0611809-A2 | Latex paints with microemulsion modifier and process for their preparation | THE GLIDDEN COMPANY (US) | 1994-08-24 | — | — | EP | disclosed |