Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 16/20 | 0.68 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358980 | 0.90 | PLA2G2A (0.66) | PLA2G2APLA2G1BPTGS2 | |
| SCHEMBL8356294 | 0.85 | PLA2G2A (0.60) | PLA2G2APLA2G1BPTGS2 | |
| SCHEMBL8356783 | 0.85 | PLA2G2A (0.59) | PLA2G2APLA2G1BPTGS2 | |
| SCHEMBL8360018 | 0.84 | PTGS2 (0.73) | PLA2G2AHDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL27550953 | 0.84 | PLA2G2A (0.57) | PLA2G2APLA2G1BHDAC3HDAC1HDAC8 | |
| SCHEMBL8355125 | 0.81 | PLA2G2A (0.53) | PLA2G2APLA2G1BHDAC3HDAC1HDAC8 | |
| SCHEMBL7961561 | 0.81 | PLA2G2A (1.00) | PLA2G2APLA2G1B | |
| SCHEMBL27473629 | 0.81 | PLA2G2A (0.54) | PLA2G2APLA2G1BHDAC3HDAC1HDAC8 | |
| SCHEMBL8645997 | 0.80 | PLA2G2A (0.83) | PLA2G2APLA2G1BPTGS2 | |
| SCHEMBL7963016 | 0.80 | PLA2G2A (1.00) | PLA2G2APLA2G1BPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |