⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9069105 | 0.77 | — | — | |
| SCHEMBL7004114 | 0.77 | — | — | |
| SCHEMBL4870074 | 0.76 | — | — | |
| SCHEMBL4871969 | 0.71 | KDM4E (0.31) | — | |
| SCHEMBL4914745 | 0.62 | — | — | |
| SCHEMBL333295 | 0.60 | — | — | |
| SCHEMBL9371337 | 0.59 | — | — | |
| SCHEMBL28558402 | 0.59 | — | — | |
| SCHEMBL24686031 | 0.56 | — | — | |
| SCHEMBL9128230 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5178839-A | — | — | None | — | — | JP | disclosed |
| EP-0515934-B1 | Microbial application of 1-thiocarbamoyl-5-hydroxy-pyrazoles, 1-thiocarbamoyl-5-hydroxy pyrazoles and process for their fabrication | BAYER AG (DE) | 1998-09-09 | — | — | EP | disclosed |
| EP-0515934-B1 | Microbial application of 1-thiocarbamoyl-5-hydroxy-pyrazoles, 1-thiocarbamoyl-5-hydroxy pyrazoles and process for their fabrication | BAYER AG (DE) | 1998-09-09 | — | — | EP | disclosed |
| US-5672617-A | Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-30 | — | — | US | disclosed |
| US-5672617-A | Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-30 | — | — | US | disclosed |
| US-5510365-A | SUPPRESSION OF TUMOR NECROSIS FACTOR (TNFALPHA) ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-23 | — | — | US | disclosed |
| US-5510365-A | SUPPRESSION OF TUMOR NECROSIS FACTOR (TNFALPHA) ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-23 | — | — | US | disclosed |
| US-5510365-A | SUPPRESSION OF TUMOR NECROSIS FACTOR (TNFALPHA) ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-23 | — | — | US | disclosed |
| US-5502069-A | FUNGICIDES IN PAINTS OR BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5502069-A | FUNGICIDES IN PAINTS OR BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5502069-A | FUNGICIDES IN PAINTS OR BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| EP-0638556-A1 | Medicaments containing 1-Thiocarbamoyl-5-hydroxy pyrazoles and their use as agents for the treatment of septic shock | BAYER AG (DE) | 1995-02-15 | — | — | EP | disclosed |
| EP-0638556-A1 | Medicaments containing 1-Thiocarbamoyl-5-hydroxy pyrazoles and their use as agents for the treatment of septic shock | BAYER AG (DE) | 1995-02-15 | — | — | EP | disclosed |
| EP-0638556-A1 | Medicaments containing 1-Thiocarbamoyl-5-hydroxy pyrazoles and their use as agents for the treatment of septic shock | BAYER AG (DE) | 1995-02-15 | — | — | EP | disclosed |
| JP-H05178839-A | USE OF 1-THIOCARBAMOYL-5-HYDROXY-PYRAZOLE AS MICROBICIDE AND NEW 1-THIOCARBAMOYL-5-HYDROXY-PYRAZOLE AND ITS PRODUCTION | BAYER AG | 1993-07-20 | — | — | JP | disclosed |
| EP-0515934-A1 | Microbial application of 1-thiocarbamoyl-5-hydroxy-pyrazoles, 1-thiocarbamoyl-5-hydroxy pyrazoles and process for their fabrication | BAYER AG (DE) | 1992-12-02 | — | — | EP | disclosed |
| EP-0515934-A1 | Microbial application of 1-thiocarbamoyl-5-hydroxy-pyrazoles, 1-thiocarbamoyl-5-hydroxy pyrazoles and process for their fabrication | BAYER AG (DE) | 1992-12-02 | — | — | EP | disclosed |
| EP-0515934-A1 | Microbial application of 1-thiocarbamoyl-5-hydroxy-pyrazoles, 1-thiocarbamoyl-5-hydroxy pyrazoles and process for their fabrication | BAYER AG (DE) | 1992-12-02 | — | — | EP | disclosed |