Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15484371 | 0.81 | KDM4E (0.36) | KDM4E | |
| SCHEMBL7004114 | 0.71 | — | — | |
| SCHEMBL8646100 | 0.71 | — | — | |
| SCHEMBL4870074 | 0.69 | — | — | |
| SCHEMBL173343 | 0.64 | OXTR (0.40) | KDM4E | |
| SCHEMBL17686525 | 0.64 | KDM4E (0.31) | KDM4E | |
| SCHEMBL18007577 | 0.61 | KDM4E (0.30) | KDM4E | |
| SCHEMBL4886599 | 0.60 | KDM4E (0.47) | KDM4E | |
| SCHEMBL598084 | 0.60 | KDM4E (0.50) | KDM4E | |
| SCHEMBL1064157 | 0.60 | SLC6A2 (0.35) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-20050215608-A1 | Bis-aryl thiazole derivatives | AMGEN INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2003002062-A2 | BIS-ARYL THIAZOLE DERIVATIVES | TULARIK INC. (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215608-A1 | Bis-aryl thiazole derivatives | FABP4, PC, TXNRD2 | KDM4E 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.