Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21100997 | 0.90 | GAA (0.41) | GAAMAPTKMT2AADRA2APNMT | |
| SCHEMBL29057617 | 0.86 | GAA (0.38) | GAAMAPTBRD4KMT2AADRA2A | |
| SCHEMBL30358050 | 0.86 | IGF1R (0.46) | BRD4KMT2AMEN1POLBSLC6A4 | |
| SCHEMBL3893061 | 0.86 | IGF1R (0.46) | BRD4KMT2AMEN1POLBSLC6A4 | |
| SCHEMBL862757 | 0.85 | MEN1 (0.49) | GAAMAPTKMT2AADRA2APNMT | |
| SCHEMBL7043179 | 0.84 | MAPT (0.41) | GAAMAPTKMT2AMEN1 | |
| SCHEMBL17454452 | 0.83 | GAA (0.42) | GAAMAPTBRD4KMT2AADRA2A | |
| SCHEMBL1760643 | 0.82 | ALDH1A1 (0.44) | GAAMAPT | |
| SCHEMBL6974512 | 0.82 | GAA (0.40) | GAAMAPTKMT2A | |
| SCHEMBL5563634 | 0.82 | PDE5A (0.41) | GAAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843972-A | Heterocyclic β-adrenergic agonists | PFIZER INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801060-A1 | Heterocyclic Beta-3 Adrenergenic Agonists | PFIZER INC. (US) | 1997-10-15 | — | — | EP | disclosed |